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Abstract Title:

Anti-leukemia activities of selenium nanoparticles embedded in nanotube consisted of triple-helixβ-d-glucan.

Abstract Source:

Carbohydr Polym. 2020 Jul 15 ;240:116329. Epub 2020 Apr 23. PMID: 32475588

Abstract Author(s):

Yanxia Jin, Liqin Cai, Qian Yang, Ziyi Luo, Li Liang, Yuxing Liang, Balu Wu, Lu Ding, Dongdong Zhang, Xiaojuan Xu, Lina Zhang, Fuling Zhou

Article Affiliation:

Yanxia Jin

Abstract:

Acute myeloid leukemia (AML) is a difficult therapeutic hematological tumor. It is urgent to find a non-toxic natural drug to treat AML. Herein, the selenium nanoparticles (SeNPs) embedded in nanotubes consisted of triple helixβ-(1, 3)-d-glucan (BFP) from the black fungus that were wrapped to form stable inclusion complex BFP-Se, which was self-assembled and exhibited high stability in water. In vitro, the BFP-Se significantly inhibited the proliferation of AML cells and increased the cytotoxicity on AML cells. On single-cell levels, the U937 cells were gradually swelled and lysed with BFP-Se treatment on optofluidics chips. Further, the blood and bone marrow analysis indicated the anti-leukemia effects of BFP-Se in vivo. Moreover, BFP-Se increased the total antioxidant capacity of AML cells and decreased the expression of c-Jun activation domain-binding protein 1 and thioredoxin 1. Our results suggest that this biocompatible polysaccharide nanotube containing Se nanoparticles would provide a novel strategy for AML therapy.

Study Type : Animal Study

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Sayer Ji
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