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Article Publish Status: FREE
Abstract Title:

Anti-hyperalgesic properties of ethanolic crude extract from the peels of Citrus reticulata (Rutaceae).

Abstract Source:

An Acad Bras Cienc. 2020 ;92(1):e20180793. Epub 2020 May 11. PMID: 32401835

Abstract Author(s):

Adriele C A Schneider, Ana P Batisti, Bruna L Turnes, Thiago C Martins, Maria E M Lisboa, Kauê M Custódio, Jasper Zanco, Karen S C Wilson, Ana Caroline Heymanns, Luiz A Kanis, Rachel F Magnago, Daniel F Martins, Anna P Piovezan

Article Affiliation:

Adriele C A Schneider

Abstract:

The therapeutic effects from Citrus reticulata on painful inflammatory ailments are associated to its flavonoids constituent and phytochemical studies with Citrus genus affirm that the peels have important amounts of it. These bioactive compounds have been a considerable therapeutic source and evaluate potential application of the peel extract is significant. This research aims to investigate the influence of ethanolic crude extract from the peels of Citrus reticulata and its possible mechanism of action in different animal models of pain. The extract reduced hyperalgesia in the second phase of formalin test (vehicle: 501.5± 40.0 s; C. reticulata extract 300 mg/kg: 161.8 ± 41.1 s), in the carrageenan model (vehicle at 4th h: 82.5 ± 9.6 %; C. reticulata extract 300 mg/kg at 4th h: 47.5 ± 6.5 %) and in Complete Freund's Adjuvant model (vehicle: 501.5 ± 40.0 s; C. reticulata extract 300 mg/kg: 161.8 ± 41.1 s). Thepossible contribution of opioidergic and adenosinergic systems in the anti-hyperalgesic effect of C. reticulata extract was observed after treatment, with non-selective antagonists for both systems, which produced reversal effects. In conclusion, these properties of C. reticulata extract suggest a potential therapeutic benefit in treating painful conditions.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Analgesics : CK(2569) : AC(470)

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