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Abstract Title:

Effect of ethanolic preparations of cinnamon () extract on hematologic and histometric parameters of selected organs in Alloxaninduced diabetic female albino rats.

Abstract Source:

J Diabetes Metab Disord. 2019 Dec ;18(2):505-512. Epub 2019 Nov 19. PMID: 31890676

Abstract Author(s):

Anas Sarwar Qureshi, Junaid Ghaffor, Muhammad Usman, Nazia Ehsan, Zaima Umar, Adeel Sarfraz

Article Affiliation:

Anas Sarwar Qureshi

Abstract:

Purpose: Assessment of the antidiabetic effect of cinnamon bark extract in histologic damages and some hematologic parameters in Alloxan® induced diabetic female albino rats.

Method: Thirty female albino rats weighing 150-230 g were divided into five groups ( = 6): normal (G1) and diabetic groups (intraperitoneally Alloxan®-injected) including diabetic control (G2), Getformin @ 0.25 (G3), CE @ 0.10 (G4), and CE @ 0.20 g/kg b.wt. (G5) for 49 days. Blood glucose level and weight were measured on weekly interval for the period of seven weeks (49th day). Blood samples were collected for hematologic analysis. Tissue samples from uterus, liver and kidneys were processed by routine paraffine technique. Histologic sections of uterus were studied to measure endometrial glands area and thickness of endo- and myometrium. Liver and kidneys were evaluated for diabetes-induced degenerative changes and antidiabetic effect of cinnamon extract (CE). One-way analysis of variance followed by Tukey test were used to compare the group means for each parameter.

Results: Statistical analysis revealed significant ( < 0.05) deleterious effects of diabetes on all parameters studied, however, CE recovered hematological parameters significantly ( < 0.05) as seen in G3 and G5 groups which showed significant ( < 0.05) improvement in uterus, liver and kidneys' histology. G4 significantly (P < 0.05) reduced the blood glucose at the 4th week which was maintained in subsequent weeks while G3 and G5 had significantly ( < 0.05) lowered the blood glucose from 1st week, although highly significant ( < 0.01) effect was observed during last two weeks of the study.

Conclusion: Anti-diabetic activity of cinnamon extract was found significant in Alloxan® induced hyperglycemic rats in dose-dependent manners. CE has potential to restore diabetes induced hematological disturbances and histological damages in uterus, liver and kidney due to the presence of cinnamic acid, anhydride tannin and methyl-hydroxy chalcone polymer. Hence, CE can be recommended for the management of glucose homeostasis to avoid diabetes-associated disturbances in female rats.

Study Type : Animal Study

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Sayer Ji
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