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Article Publish Status: FREE
Abstract Title:

Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice.

Abstract Source:

Evid Based Complement Alternat Med. 2011 ;2011:478246. Epub 2010 Oct 25. PMID: 19349477

Abstract Author(s):

Heng-Yuan Chang, Ming-Jyh Sheu, Chun-Hung Yang, Tsung-Chun Lu, Yuan Shiun Chang, Wen-Huang Peng, Shyh-Shyun Huang, Guan-Jhong Huang

Article Affiliation:

Heng-Yuan Chang

Abstract:

Hispolon, an active ingredient in the fungi Phellinus linteus was evaluated with analgesic and anti-inflammatory effects. Treatment of male ICR mice with hispolon (10 and 20 mg/kg) significantly inhibited the numbers of acetic acid-induced writhing response. Also, our result showed that hispolon (20 mg/kg) significantly inhibited the formalin-induced pain in the later phase (P<.01). In the anti-inflammatory test, hispolon (20 mg/kg) decreased the paw edema at the fourth and fifth hour after λ-carrageenin (Carr) administration, and increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRx) in the liver tissue. We also demonstrated that hispolon significantly attenuated the malondialdehyde (MDA) level in the edema paw at the fifth hour after Carr injection. Hispolon (10 and 20 mg/kg) decreased the nitric oxide (NO) levels on both the edema paw and serum level at the fifth hour after Carr injection. Also, hispolon (10 and 20 mg/kg) diminished the serumTNF-α at the fifth hour after Carr injection. The anti-inflammatory mechanisms of hispolon might be related to the decrease in the level of MDA in the edema paw by increasing the activities of SOD, GPx and GRx in the liver. It probably exerts anti-inflammatory effects through the suppression of TNF-α and NO.

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