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Abstract Title:

The ameliorating effect of Rosa roxburghii against ethanol-induced psychomotor alterations in rats.

Abstract Source:

Am J Drug Alcohol Abuse. 2014 Jan ;40(1):75-81. Epub 2013 Nov 22. PMID: 24266614

Abstract Author(s):

Irene Joy I Dela Peña, Seo Young Yoon, June Bryan de la Peña, Subin Park, Bitna Yoon, Hee Jin Kim, Se Hee Paek, Yonh Ki Seo, Byoung Seok Moon, Jae Hoon Cheong

Article Affiliation:

Irene Joy I Dela Peña

Abstract:

BACKGROUND: Ethanol (EtOH) is one of the oldest recreational substances known to man, primarily taken because it induces a sense of well-being (euphoric effects) and relaxation (anxiolytic effects). EtOH use entails various negative consequences. Of particular interest are EtOH-induced psychomotor alterations, because of its immediate manifestation and adverse consequences. Rosa roxburghii (RR), a wild plant of Southwest China, has gained attention on account of its numerous beneficial effects on the immune, nervous, and cardiovascular systems.

OBJECTIVE: In the present study we assessed the effects of Rosa roxburghii (RR) on EtOH-induced psychomotor alterations in rats.

METHODS: Sprague Dawley rats were orally administered distilled water (control group) or ethanol (4 g/kg BW) (EtOH-group) to induce psychomotor alterations. RR extract (25, 50, and 100 mg/kg, p.o.) was administered 30 min before EtOH treatment (RR-group). EtOH-induced psychomotor alterations were evaluated in the open-field, accelerating rotarod, hanging wire, and cold swimming tests. Behavioral evaluation and hematological analysis (EtOH and acetaldehyde concentration) were done at 1, 2, 4 and 8 hours after EtOH administration.

RESULTS: The EtOH group showed psychomotor alterations as compared with the control group. These EtOH-induced psychomotor alterations were directly related to the rise in blood ethanol and acetaldehyde concentrations. Pre-treatment of RR significantly improved EtOH-induced psychomotor alterations on open-field, accelerating rotarod, hanging wire, and cold swimming tests. These improvements in psychomotor performance coincided with the decreased blood ethanol and acetaldehyde levels observed in the RR-treated group.

CONCLUSION: These results suggest that RR has ameliorating effects against EtOH-induced psychomotor alterations.

Study Type : Animal Study

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