Abstract Title:

Obesity - extending the hygiene hypothesis.

Abstract Source:

Pak J Biol Sci. 2007 May 1;10(9):1544-6. PMID: 19710516

Abstract Author(s):

Erika Isolauri, Marko Kalliomäki, Samuli Rautava, Seppo Salminen, Kirsi Laitinen

Article Affiliation:

Department of Pediatrics, Functional Foods Forum, and Department of Biochemistry and Food Chemistry, University of Turku, Turku University Central Hospital, Turku, Finland. erika.isolauri@utu.fi


The hygiene hypothesis proposes that the growing epidemic of atopic eczema, allergic rhinoconjunctivitis and asthma is related to reduced exposure to microbes at an early age as a result of environmental changes in the industrialized world. These include improved sanitation and living conditions, vaccinations and antimicrobial therapy, together with declining family size and changes in dietary intake. Recent scientific advances demonstrate that the hygiene hypothesis needs to be extended in three respects. Firstly, rigorous research in the field of probiotics points to the importance of the collective composition and the compositional development of the gut microbiota in consolidation of healthy immune responsiveness. Secondly, immunomodulatory and suppressive immune responses have been shown to complement the original immunological basis of the hygiene hypothesis, the so-called T helper 1/T helper 2 paradigm. Thirdly, host-microbe interaction appears to affect the risk of developing not only atopic disease but also other inflammatory Western lifestyle diseases, including obesity. The results of experimental studies suggest that deviations in gut microbiota composition predispose to excessive energy storage and obesity, and, more recently in humans, aberrant compositional development of the gut microbiota has been shown to precede overweight, inviting enormous possibilities to reach preventive and therapeutic applications in weight management.

Study Type : Review

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.