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Abstract Title:

Alteration of adaptive behaviors of progeny after maternal mobile phone exposure.

Abstract Source:

Environ Sci Pollut Res Int. 2018 Apr ;25(11):10894-10903. Epub 2018 Feb 3. PMID: 29397508

Abstract Author(s):

Nicolas Petitdant, Anthony Lecomte, Franck Robidel, Christelle Gamez, Kelly Blazy, Anne-Sophie Villégier

Article Affiliation:

Nicolas Petitdant

Abstract:

Exposure of pregnant women to radiofrequency (RF) devices raises questions on their possible health consequences for their progeny. We examined the hazard threshold of gestational RF on the progeny's glial homeostasis, sensory-motor gating, emotionality, and novelty seeking and tested whether maternal immune activation would increase RF toxicity. Pregnant dams were daily restrained with loop antennas adjoining the abdomen (fetus body specific absorption rates (SAR): 0, 0.7, or 2.6 W/kg) and received three lipopolysaccharide (LPS) intra-peritoneal injections (0 or 80 μg/kg). Scores in the prepulse startle inhibition, fear conditioning, open field, and elevated plus maze were assessed at adolescence and adulthood. Glial fibrillary acidic protein (GFAP) and interleukines-1β(ILs) were quantified. LPS induced a SAR-dependent reduction of the prepulse startle inhibition in adults. Activity in the open field was reduced at 2.6 W/kg at adolescence. GFAP and ILs, emotional memory, and anxiety-related behaviors were not modified. These data support the hypothesis that maternal immune activation increased the developmental RF exposure-induced long-term neurobiological impairments. These data support the fact that fetuses who receive combined environmental exposures with RF need special attention for protection.

Study Type : Animal Study

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