Abstract Title:

Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.

Abstract Source:

Med Hypotheses. 2007;69(4):957-8. Epub 2007 Apr 23. PMID: 17451887

Abstract Author(s):

Agnieszka Pastuszka, Konstanty Slusarczyk, Tomasz Koszutski, Henryk Kawalski, Grzegorz Kudela


It has been recently observed that the urothelial expression of the chemokine fractalkine (CX3CL1) and its receptor (CX3CR1) is markedly increased in a mouse model of chronic cystitis . In this regard, Yuridullah et al. demonstrated a robust upregulation of both CXCL1 and CXCR1 in the urothelium following chronic cyclophosphamide (CYP)-induced cystitis in the rat . Because CYP-induced cystitis closely resembles the features of interstitial cystitis in humans , these observations establish down regulation of fractalkine as a potential target for the therapy of this common clinical entity. We hypothesize that such a therapeutic effect could be achieved via administration of alpha-lipoic acid (ALA), a naturally occurring disulfide compound . There are two major lines of evidence supporting this hypothesis: first, ALA has been demonstrated to act as an effective agent to reduce fractalkine mRNA and protein expression as well as fractalkine-mediated inflammatory processes ; second, ALA has the capacity to inhibit TNF-alpha-induced expression of fractalkine . Intriguingly, a recent study has also shown a significant reduction in antioxidant defense parameters in a rat model of chronic cystitis . Accordingly, ALA could reverse the detrimental effects of high levels of oxidative stress in bladder inflamed tissue due to its potent antioxidant activity . Finally, ALA has been shown to prevent the contractile dysfunction in rat urinary bladder strips . Since bladder inflammation may significantly influence regulation of detrusor activity , we speculate that ALA could prevent bladder hyperreflexia induced by chronic bladder inflammation.

Study Type : Human Study

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