Article Publish Status: FREE
Abstract Title:

The Effects ofCream on the Expression of CD4and CD8Lymphocytes in Skin Wound Healing.

Abstract Source:

J Trop Med. 2018 ;2018:6218303. Epub 2018 Feb 15. PMID: 29666657

Abstract Author(s):

Yos Adi Prakoso, Kurniasih

Article Affiliation:

Yos Adi Prakoso


The aim of this study is to explore the effect of topical application ofon skin wound healing. Thirty-six male Sprague-Dawley rats weighing 150-200 grams were divided into four groups. All groups were anesthetized, shaved, and exposed to round full-thickness punch biopsy on the back: group I (control); group II (treated with 1%cream); group III (treated with 2%cream); and group IV (treated with madecassol®). The treatments were given once a day. Macroscopic and microscopic examination were observed at 5, 10, and 15 days after skin biopsy. Skin specimens were prepared for histopathological study using H&E stain and IHC stain against CD4and CD8lymphocytes. All the data were analyzed using SPSS16. The result showed that topical application of 1% and 2%cream significantly reduced the percentage of the wound, leucocytes infiltration, angiogenesis, and expression of CD8lymphocytes and increased the epidermal thickness and the expression of CD4lymphocytes (≤ 0,05). There was no significant difference in the number of fibroblasts in all groups. Topical application of 1% and 2%cream has wound healing potential via their ability to increase the ratio of CD4/CD8lymphocytes in the wound area.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)

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