Article Publish Status: FREE
Abstract Title:

The Effects of Aloe vera on Wound Healing in Cell Proliferation, Migration, and Viability.

Abstract Source:

Wounds. 2018 Sep ;30(9):263-268. PMID: 30256753

Abstract Author(s):

Eric Teplicki, Qianli Ma, David E Castillo, Mina Zarei, Adam P Hustad, Juan Chen, Jie Li

Article Affiliation:

Eric Teplicki


INTRODUCTION: Aloe vera is sometimes used as a folk remedy for minor wounds and burns, but its mechanisms of action in wound healing are unclear.

OBJECTIVE: In this study, the authors evaluate the effects of A vera on wound healing.

MATERIALS AND METHODS: In vitro analyses of cell proliferation and migration were conducted on normal human primary skin fibroblasts and keratinocytes in growth media with A vera solution and preservatives at various concentrations. Growth media with preservatives but without A vera solution served as the control.

RESULTS: Aloe vera had significant stimulatory effects on cell proliferation and migration of both fibroblasts and keratinocytes. Surprisingly, A vera also exhibited strong protective effects on preservative-induced keratinocyte death. Keratinocytes in the growth media with both the preservatives and A vera had dramatically higher viability than cells in the control media without A vera.

CONCLUSIONS: The results suggest A vera accelerates wound healing by promoting the proliferation and migration of fibroblasts and keratinocytes and by protecting keratinocytes from preservative-induced death.

Study Type : In Vitro Study

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