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Abstract Title:

Aerobic Exercise Decreases Lung Inflammation by IgE Decrement in an OVA Mice Model.

Abstract Source:

Int J Sports Med. 2017 Jun ;38(6):473-480. Epub 2017 Apr 7. PMID: 28388779

Abstract Author(s):

Deborah Camargo Hizume-Kunzler, Flavia R Greiffo, Bárbara Fortkamp, Gabriel Ribeiro Freitas, Juliana Keller Nascimento, Thayse Regina Bruggemann, Leonardo Melo Avila, Adenir Perini, Franciane Bobinski, Morgana Duarte Silva, Fernanda Rocha Lapa, Rodolfo Paula Vieira, Verônica Vargas Horewicz, Adair Roberto Soares Dos Santos, Kelly Cattelan Bonorino

Article Affiliation:

Deborah Camargo Hizume-Kunzler

Abstract:

Aerobic exercise (AE) reduces lung function decline and risk of exacerbations in asthmatic patients. However, the inflammatory lung response involved in exercise during the sensitization remains unclear. Therefore, we evaluated the effects of exercise for 2 weeks in an experimental model of sensitization and single ovalbumin-challenge. Mice were divided into 4 groups: mice non-sensitized and not submitted to exercise (Sedentary, n=10); mice non-sensitized and submitted to exercise (Exercise, n=10); mice sensitized and exposed to ovalbumin (OVA, n=10); and mice sensitized, submitted to exercise and exposed to OVA (OVA+Exercise, n=10). 24 h after the OVA/saline exposure, we counted inflammatory cells from bronchoalveolar fluid (BALF), lung levels of total IgE, IL-4, IL-5, IL-10 and IL-1ra, measurements of OVA-specific IgG1 and IgE, and VEGF and NOS-2 expression via western blotting. AE reduced cell counts from BALF in the OVA group (p<0.05), total IgE, IL-4 and IL-5 lung levels and OVA-specific IgE and IgG1 titers (p<0.05). There was an increase of NOS-2 expression, IL-10 and IL-1ra lung levels in the OVA groups (p<0.05). Our results showed that AE attenuated the acute lung inflammation, suggesting immunomodulatory properties on the sensitization process in the early phases of antigen presentation in asthma.

Study Type : Animal Study

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