Abstract Title:

[Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse].

Abstract Source:

Am J Chin Med. 2006;34(3):503-9. PMID: 16642617

Abstract Author(s):

Yu Fu, Jian-chun Yu, Xiao-rong Ding, Jing-xian Han

Article Affiliation:

First Affiliated Hospital of Tianjin College of TCM, Tianjin 300193, China.

Abstract:

OBJECTIVE: To probe the mechanism of acupuncture for anti-aging.

METHODS: In the senescence accelerated mouse the SAMP10 and the SAMR1, by using RT-PCR and DIG-labeled Northern blot technique, the expression differences of HSP84 and HSP86 genes in whole brain, cortex and hippocampus in the 4 groups,8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group were investigated.

RESULTS: In the SAMP10 control group, the expression of HSP84 and HSP86 were down-regulated in the whole brain, the cortex and the hippocampus, and they were up-regulated after acupuncture, tending to the normal group.

CONCLUSION: Brain aging of the SAMP10 mouse is related with abnormal expression of HSP84 and HSP86 genes, and acupuncture can strengthen the protection of cells, inhibit apoptosis and anti-oxidative stress through regulating expression of HSP84 and HSP86, hence anti-aging.

Study Type : Animal Study

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Sayer Ji
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