Abstract Title:

Effects of acupuncture on expressions of the transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mice.

Abstract Source:

J Tradit Chin Med. 2009 Mar;29(1):54-9. PMID: 19514190

Abstract Author(s):

Yu Fu, Jian-chun Yu, Xiao-rong Ding, Jingoxian Han

Article Affiliation:

The First Hospital Affiliated to Tianjin College of Traditional Chinese Medicine, Tianjin 300193, China.


OBJECTIVE: To explore the mechanism of acupuncture for delaying aging.

METHODS: Using the senescence accelerated mouse pattern SAMP10 and the normal aging mice SAMR1 as models and applying RT-PCR and digoxin (DIG)-labeled Northern blot technique to observe expressions of NF-E2, YB-1, LRG47 genes in the forebrain, cortex and hippocampus in a 8-month old SAMR1 control group, a 8-month old SAMP10 control group, a 8-month old SAMP10 acupuncture group and a 8-month old SAMP10 non-point stimulation group.

RESULTS: In the SAMP10 control group, the expressions of NF-E2, YB-1 and LRG47 were down-regulated in the forebrain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.

CONCLUSION: The brain aging of the SAMP10 mice is related with abnormal expressions of NF-E2, YB-1 and LRG47 genes; and acupuncture can regulate the expressions of NF-E2, YB-1 and LRG47 genes, strengthening the functions of erythrocyte series, increasing the proliferation of cells and enhancing the cellular immune function in anti-bacteria, hence delaying aging.

Study Type : Animal Study
Additional Links
Therapeutic Actions : Acupuncture : CK(3141) : AC(370)
Pharmacological Actions : Immunostimulatory : CK(633) : AC(192)

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