Abstract Title:

Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway.

Abstract Source:

J Dermatol Sci. 2015 Aug ;79(2):101-9. Epub 2015 Aug 1. PMID: 26049685

Abstract Author(s):

Wei Xing, Wei Guo, Cun-Hua Zou, Ting-Ting Fu, Xiang-Yun Li, Ming Zhu, Jun-Hua Qi, Jiao Song, Chen-Hui Dong, Zhuang Li, Yong Xiao, Pei-Song Yuan, Hong Huang, Xiang Xu

Article Affiliation:

Wei Xing


BACKGROUND: Acemannan is a bioactive polysaccharides promoting tissue repair. However, the roles of acemannan in skin wound healing and the underlying molecular mechanisms are largely unclear.

OBJECTIVE: The goal of this study is to investigate the positive role of acemannan in cutaneous wound healing and its mechanism.

METHODS: Mouse skin wound model and skin primary fibroblasts were used to demonstrate the positive effect of acemannan on cutaneous wound healing. The expressions of cell proliferation nuclear antigen ki-67, cyclin D1 and activity of AKT/mTOR signaling were analyzed in acemannan-treated fibroblasts and mice. Rapamycin and AKT inhibitor VIII were used to determine the key role of AKT/mTOR signaling in acemannan-promoting cutaneous wound healing.

RESULTS: We found that acemannan significantly accelerated skin wound closure and cell proliferation. Acemannan promoted the expression of cyclin D1 in cultured fibroblasts, which was mediated by AKT/mTOR signal pathway leading to enhanced activity of the eukaryotic translation initiation factor-4F (eIF4F) and increased translation of cyclin D1. In contrast, pharmaceutical blockade of AKT/mTOR signaling by mTOR inhibitor rapamycin or AKT inhibitor VIII abolished acemannan-induced cyclin D1 translation and cell proliferation. In vivo studies confirmed that the activation of AKT/mTOR by acemannan played a key role in wound healing, which could be reversed by rapamycin.

CONCLUSION: Acemannan promoted skin wound healing partly through activating AKT/mTOR-mediated protein translation mechanism, which may represent an alternative therapy approach for cutaneous wound.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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