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Abstract Title:

Effect of radiofrequency electromagnetic field exposure on in vitro models of neurodegenerative disease.

Abstract Source:

Bioelectromagnetics. 2009 Oct ;30(7):564-72. PMID: 19479910

Abstract Author(s):

Giovanna Del Vecchio, Alessandro Giuliani, Mercedes Fernandez, Pietro Mesirca, Ferdinando Bersani, Rosanna Pinto, Lucia Ardoino, Giorgio A Lovisolo, Luciana Giardino, Laura Calzà

Article Affiliation:

Giovanna Del Vecchio

Abstract:

In this work we tested viability, proliferation, and vulnerability of neural cells, after continuous radiofrequency (RF) electromagnetic fields exposure (global system for mobile telecommunications (GSM) modulated 900 MHz signal at a specific absorption rate (SAR) of 1 W/kg and maximum duration 144 h) generated by transverse electromagnetic cells. We used two cellular systems, SN56 cholinergic for example, SN56 cholinergic cell line and rat primary cortical neurons, and well-known neurotoxic challenges, such as glutamate, 25-35AA beta-amyloid, and hydrogen peroxide. Exposure to RF did not change viability/proliferation rate of the SN56 cholinergic cells or viability of cortical neurons. Co-exposure to RF exacerbated neurotoxic effect of hydrogen peroxide in SN56, but not in primary cortical neurons, whereas no cooperative effects of RF with glutamate and 25-35AA beta-amyloid were found. These data suggest that only under particular circumstances exposure to GSM modulated, 900 MHz signal act as a co-stressor for oxidative damage of neural cells.

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